Cancer Biology Journal Club, The University of Iowa
Spring 2021, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact:  Tel 319/335-8019
Zoom Link:
Meeting ID: 968 9142 8453

January 25, 2021
Presenter:  Yuna Bayanbold
Paper:  Visnes T, Benítez-Buelga C, Cázares-Körner A, Sanjiv K, Hanna BMF, Mortusewicz O, Rajagopal V, Albers JJ, Hagey DW, Bekkhus T, Eshtad S, Baquero JM, Masuyer G, Wallner O, Müller S, Pham T, Göktürk C, Rasti A, Suman S, Torres-Ruiz R, Sarno A, Wiita E, Homan EJ, Karsten S, Marimuthu K, Michel M, Koolmeister T, Scobie M, Loseva O, Almlöf I, Unterlass JE, Pettke A, Boström J, Pandey M, Gad H, Herr P, Jemth AS, El Andaloussi S, Kalderén C, Rodriguez-Perales S, Benítez J, Krokan HE, Altun M, Stenmark P, Berglund UW, Helleday T. Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Res. 2020 Dec 2;48(21):12234-12251. PMID: 33211885; PMCID: PMC7708037.
doi: 10.1093/nar/gkaa1048

February 8, 2021
Presenter: Sam Rodman
Paper: Brown JL, Lawrence MM, Ahn B, Kneis P, Piekarz KM, Qaisar R, Ranjit R, Bian J, Pharaoh G, Brown C, Peelor FF 3rd, Kinter MT, Miller BF, Richardson A, Van Remmen H. Cancer cachexia in a mouse model of oxidative stress. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1688-1704. Epub 2020 Sep 12. PMID: 32918528; PMCID: PMC7749559.
doi: 10.1002/jcsm.12615

February 22, 2021
Presenter:  Dr. Michelle Giedt
Paper:  Rozeveld CN, Johnson KM, Zhang L, Razidlo GL. KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL. Cancer Res. 2020 Nov 15;80(22):4932-4945. CAN-20-1255. Epub 2020 Aug 19. PMID: 32816911; PMCID: PMC7669720.
doi: 10.1158/0008-5472

March 8, 2021
Presenter:  Maddie Hines
Paper: Zhong W, Weiss HL, Jayswal RD, Hensley PJ, Downes LM, St Clair DK, Chaiswing L. Extracellular redox state shift: A novel approach to target prostate cancer invasion. Free Radic Biol Med. 2018 Mar;117:99-109 Epub 2018 Feb 2. PMID: 29421238; PMCID: PMC5845758.
doi: 10.1016/j.freeradbiomed.2018.01.023

March 22, 2021
Presenter: Dr. Ann Miller, PhD
Paper: Oresta B, Pozzi C, Braga D, Hurle R, Lazzeri M, Colombo P, Frego N, Erreni M, Faccani C, Elefante G, Barcella M, Guazzoni G, Rescigno M. Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer. Sci Transl Med. 2021 Jan 6;13(575):eaba6110. PMID: 33408185.
doi: 10.1126/scitranslmed.aba6110

April 5, 2021 Dr. Vanneste is unable to present today, Dr. Spitz will stand in her place. New Paper listed below
Presenter: Dr. Douglas Spitz
Paper: Sandoval-Acuña C, Torrealba N, Tomkova V, Jadhav SB, Blazkova K, Merta L, Lettlova S, Adamcová MK, Rosel D, Brábek J, Neuzil J, Stursa J, Werner L, Truksa J. Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy. Cancer Res. 2021 Mar 8:canres.1628.2020. Epub ahead of print. PMID: 33685989.
doi: 10.1158/0008-5472.CAN-20-1628.

Presenter:  Marion Vanneste
Paper: Jaewang Lee, Ji Hyeon You, Min-Su Kim, Jong-Lyel Roh. Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer. Redox Biology 37 (2020) 101697.      PMID: 32896720 PMCID: PMC7484553 DOI: 10.1016/j.redox.2020.101697.

April 19, 2021
Presenter:  Laura Pietrok
Paper: Byun JK, Park M, Lee S, Yun JW, Lee J, Kim JS, Cho SJ, Jeon HJ, Lee IK, Choi YK, Park KG. Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity. Mol Cell. 2020 Nov 19;80(4):592-606.e8. Epub 2020 Nov 6. PMID: 33159855
doi: 10.1016/j.molcel.2020.10.015

May 3, 2021
Presenter:  Jyoti Arora
Paper: Zheng P, Ding B, Shi R, Jiang Z, Xu W, Li G, Ding J, Chen X. A Multichannel Ca2+ Nanomodulator for Multilevel Mitochondrial Destruction-Mediated Cancer Therapy. Adv Mater. 2021 Mar 6:e2007426. Epub ahead of print. PMID: 33675268.
doi: 10.1002/adma.202007426