Cancer Biology Journal Club, The University of Iowa
Spring 2022, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact: douglas-spitz@uiowa.edu Tel 319/335-8019

 

January 24, 2022

Presenter: Doug Spitz 

Paper:  Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM. Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science. 2021 Dec 3;374(6572):1227-1237. Epub 2021 Dec 2. PMID: 34855504.

doi: 10.1126/science.abi7495

 

February 7, 2022

Presenter: Sam Rodman

Paper: Liu T, Zhou L, Xiao Y, Andl T, Zhang Y. BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma. Cancer Res. 2022 Jan 21. Epub ahead of print. PMID: 35064015.
doi: 10.1158/0008-5472.CAN-21-0614

 

February 21, 2022

Presenter:  Mike Liman

Paper:  Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 Apr 3;368(6486):85-89. PMID: 32241947; PMCID: PMC7681911.

doi: 10.1126/science.aaw9872

 

March 7, 2022

Presenter: Casey Pulliam

Paper:  Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, Das M, Fang B, Poyurovsky MV, Gan B. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience. 2021 May 25;24(6):102649. PMID: 34151236; PMCID: PMC8193145.

doi: 10.1016/j.isci.2021.102649

 

March 21, 2022

Presenter: Laura Pietrok

Paper: Dotsu Y, Muraoka D, Ogo N, Sonoda Y, Yasui K, Yamaguchi H, Yagita H, Mukae H, Asai A, Ikeda H. Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors. J Immunother Cancer. 2022 Feb;10(2):e003958. PMID: 35115364; PMCID: PMC8814813.

doi: 10.1136/jitc-2021-003958

 

April 4, 2022 
Presenter: Dr. Ali Razzaghi
Paper: Chen H, Yang H, Zhu X, Yadav T, Ouyang J, Truesdell SS, Tan J, Wang Y, Duan M, Wei L, Zou L, Levine AS, Vasudevan S, Lan L. m5C modification of mRNA serves a DNA damage code to promote homologous recombination. Nat Commun. 2020 Jun 5;11(1):2834. PMID: 32503981; PMCID: PMC7275041.
doi: 10.1038/s41467-020-16722-7

 

April 18, 2022

Presenter:  Dr. Michelle Giedt

Paper:  Lin S, Huang C, Gunda V, Sun J, Chellappan SP, Li Z, Izumi V, Fang B, Koomen J, Singh PK, Hao J, Yang S. Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments. Cell Rep. 2019 Sep 10;28(11):2824-2836.e8. PMID: 31509745; PMCID: PMC6759858.

doi: 10.1016/j.celrep.2019.08.011

 

May 2, 2022

Presenter:  Dr. Gloria Chen

Paper: Krauß L, Urban BC, Hastreiter S, Schneider C, Wenzel P, Hassan Z, Wirth M, Lankes K, Terrasi A, Klement C, Cernilogar FM, Öllinger R, de Andrade Krätzig N, Engleitner T, Schmid RM, Steiger K, Rad R, Krämer OH, Reichert M, Schotta G, Saur D, Schneider G. HDAC2 Facilitates Pancreatic Cancer Metastasis. Cancer Res. 2022 Feb 15;82(4):695-707. PMID: 34903606.

doi: 10.1158/0008-5472.CAN-20-3209