CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY
SCHEDULE OF PRESENTATIONS
Spring 2024 (Director: Dr. Douglas Spitz)
11:30 AM - 12:30 PM, Every Other Monday, Room B180 Med Labs

Presentations for Spring 2024:

January 15, 2024
Office Closed, MLK Jr. Day

January 22, 2024

Presentation: Redox Biology Virtual Seminar: Mitochondria as Signaling Organelles

Speaker: Navdeep Chandel, PhD

February 5, 2024

Presenter: Douglas Spitz

Paper: Wu H, Zhao X, Hochrein SM, Eckstein M, Gubert GF, Knöpper K, Mansilla AM, Öner A, Doucet-Ladevèze R, Schmitz W, Ghesquière B, Theurich S, Dudek J, Gasteiger G, Zernecke A, Kobold S, Kastenmüller W, Vaeth M. Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming. Nat Commun. 2023 Oct 27;14(1):6858. doi: 10.1038/s41467-023-42634-3. PMID: 37891230; PMCID: PMC10611730.

February 19, 2024

Presenter:  Douglas Spitz

Paper: Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P. 7-Dehydrocholesterol dictates ferroptosis sensitivity. Nature. 2024 Feb;626(7998):411-418. doi: 10.1038/s41586-023-06983-9. Epub 2024 Jan 31. PMID: 38297130.

March 4, 2024

Presenter: Amanda Pope

Paper: Lee E, Choi A, Jun Y, Kim N, Yook JI, Kim SY, Lee S, Kang SW. Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling. Redox Biol. 2020 Jan;29:101391. doi: 10.1016/j.redox.2019.101391. Epub 2019 Nov 26. PMID: 31926619; PMCID: PMC6906704.

March 18, 2024

Presenter: Douglas Spitz

Paper: Si X, Shao M, Teng X, Huang Y, Meng Y, Wu L, Wei J, Liu L, Gu T, Song J, Jing R, Zhai X, Guo X, Kong D, Wang X, Cai B, Shen Y, Zhang Z, Wang D, Hu Y, Qian P, Xiao G, Huang H. Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation. Cell Metab. 2024 Jan 2;36(1):176-192.e10. doi: 10.1016/j.cmet.2023.12.010. PMID: 38171332.

April 1, 2024

Presenter: Casey Pulliam

Paper: Recouvreux MV, Grenier SF, Zhang Y, Esparza E, Lambies G, Galapate CM, Maganti S, Duong-Polk K, Bhullar D, Naeem R, Scott DA, Lowy AM, Tiriac H, Commisso C. Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma. Nat Cancer. 2024 Jan;5(1):100-113. doi: 10.1038/s43018-023-00649-1. Epub 2023 Oct 9. PMID: 37814011; PMCID: PMC10956382.

April 15, 2024

Presenter: Kelly Hubert

Paper: Lu MJ, Busquets J, Impedovo V, Wilson CN, Chan HR, Chang YT, Matsui W, Tiziani S, Cambronne XA. SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells. Cell Metab. 2024 Apr 2;36(4):808-821.e6. doi: 10.1016/j.cmet.2024.01.013. Epub 2024 Feb 14. PMID: 38354740; PMCID: PMC10990793.

April 29, 2024

Presenter: Melissa Fath

Paper: Singhal R, Mitta SR, Das NK, Kerk SA, Sajjakulnukit P, Solanki S, Andren A, Kumar R, Olive KP, Banerjee R, Lyssiotis CA, Shah YM. HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. J Clin Invest. 2021 Jun 15;131(12):e143691. doi: 10.1172/JCI143691. PMID: 33914705; PMCID: PMC8203462.